Oligonucleotides and custom chemicals
Custom synthesis of oligonucleotides
· oligonucleotides of DNA nature –
· primers,
· antisense oligonucleotides,
· labelled at 3’ and 5’ terminus oligonucleotides:
· acridine labelling,
· biotin labelling,
· cholesterol labelling,
· cyanine labelling, DNP labelling,
· fluoresceine labelling,
· rhodamine labelling,
· introduction of different quenchers, etc.
· oligonucleotides of RNA nature –
si RNAs,
microRNAs, etc.
· Oligonucleotides with modified 3’ and 5’ terminus –
amino,
carboxyl,
carboxyl NHS,
thiol, etc.
· Oligonucleotides with modified sugar moiety –
2’-deoxy-2’-fluoro,
2’-deoxy-2’fluoroarabino
· Preparation of custom libraries employing trimer phosphoroamidites.
· Custom synthesis of peptide oligonucleotide conjugates via disulphide bond (peptide synthesis is not provided)